What happens if a related ligand binds to a binding site?

What happens if a related ligand binds to a binding site?

In protein-ligand binding, the ligand is usually a molecule which produces a signal by binding to a site on a target protein. The binding typically results in a change of conformational isomerism (conformation) of the target protein.

What is a ligand binding site?

In biochemistry and molecular biology, a binding site is a region on a macromolecule such as a protein that binds to another molecule with specificity. The binding partner of the macromolecule is often referred to as a ligand.

How does a ligand binding to a channel cause a cellular response?

When a ligand binds to the extracellular domain, a signal is transferred through the membrane, activating the enzyme. Activation of the enzyme sets off a chain of events within the cell that eventually leads to a response.

What does the binding site do?

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What happens to the ion channel when the ligand attaches to the ligand binding site?

When a ligand binds to the extracellular region of the channel, there is a conformational change in the protein’s structure that allows ions such as sodium, calcium, magnesium, and hydrogen to pass through. G-protein-linked receptors bind a ligand and activate a membrane protein called a G-protein.

What binds to a binding site?

A binding site is a position on a protein that binds to an incoming molecule that is smaller in size comparatively, called ligand. In proteins, binding sites are small pockets on the tertiary structure where ligands bind to it using weak forces (non-covalent bonding).

What are binding sites on enzymes?

The binding site on enzymes is often referred to as the active site because it contains amino acids that both bind the substrate and aid in its conversion to product. You can often recognize that a protein is an enzyme by its name. Many enzyme names end with –ase.

What is ligand mediated dimerization?

Recent structural studies reveal the molecular basis for ligand binding specificity and how ligand binding induces receptor dimerization. Receptor dimerization is mediated by receptor-receptor interactions in which a loop protruding from neighboring receptors mediates receptor dimerization and activation.

What causes dimerization?

Molecular dimers are often formed by the reaction of two identical compounds e.g.: 2A → A-A. In this example, monomer “A” is said to dimerise to give the dimer “A-A”. An example is a diaminocarbene, which dimerise to give a tetraaminoethylene: 2 C(NR2)2 → (R2N)2C=C(NR2)

Where does the ligand bind on the receptor?

The ligand crosses the plasma membrane and binds to the receptor in the cytoplasm. The receptor then moves to the nucleus, where it binds DNA to regulate transcription.