Is a seminoma cancer?
A type of cancer that begins in germ cells in males. Germ cells are cells that form sperm in males or eggs in females. Seminomas occur most often in the testicle, but they may also occur in other areas of the body, such as the brain, chest, or abdomen.
Where does seminoma occur?
The main types of germ cell tumors (GCTs) in the testicles are seminomas and non-seminomas. These types occur about equally. Many testicular cancers contain both seminoma and non-seminoma cells. These mixed germ cell tumors are treated as non-seminomas because they grow and spread like non-seminomas.
What is the prognosis of seminoma?
The 3-year survival rate for patients diagnosed with typical testicular seminoma was 100%, 93.8% for cases with testicular seminoma combined with embryonal carcinoma, and 84.6% for those with testicular seminoma combined with embryonal carcinoma and teratoma.
What is the prognosis of testicular seminoma with syncytiotrophoblastic giant cells?
Conclusions: Testicular seminoma with syncytiotrophoblastic giant cells and increased serum β-hCG is a rare subtype, which occurs mostly in young people, sensitive to chemotherapy postoperatively and with a relatively good prognosis. Keywords: chorionic gonadotropin; clinicopathology; prognosis; syncytiotrophoblastic giant cell; seminoma.
Which immunohistochemistry findings are characteristic of seminoma with syncytiotrophoblastic giant cells?
Results: All the 3 cases were typical seminoma with syncytiotrophoblastic giant cells. Immunohistochemistry showed strong expressions of CD117 OCT-4, SALL4 and PLAP in diffuse tumor cells, and that of hCG in syncytiotrophoblastic cells.
What is the formation of syncytiotrophoblast?
Formation. The syncytiotrophoblast lacks proliferative capacity and instead is maintained by fusion of underlying cytotrophoblast cells. This fusion is assisted by syncytin, a protein that was integrated into mammalian genomes from an endogenous retrovirus.
What percentage of testicular neoplasms are seminomas?
Introduction Testicular seminoma accounts for 40% of primary testicular neoplasms, with 70–85% of patients presenting with disease confined to the testis (Stage I), while 15–20% present with infra-diaphragmatic lymphadenopathy (Stage II) (1).