What is C-kit a marker for?

What is C-kit a marker for?

Measuring the amount of c-kit in tumor tissue may help diagnose cancer and plan treatment. C-kit is a type of receptor tyrosine kinase and a type of tumor marker. Also called CD117 and stem cell factor receptor.

Is C-kit the same as CD117?

The CD117 gene, officially known as “KIT proto-oncogene receptor tyrosine kinase” (GenBank ID: 3815), is also more commonly known as c-kit, kit, or stem cell factor receptor. CD117 was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit.

What is positive for KIT?

Other KIT-positive normal cells include epithelial cells in skin adnexa, breast, and subsets of cerebellar neurons. KIT positivity has been variably reported in sarcomas such as angiosarcoma, Ewing sarcoma, synovial sarcoma, leiomyosarcoma, and MFH; results of the last three are controversial.

What cells are CD117 positive?

It binds to a substance called stem cell factor (SCF), which causes certain types of blood cells to grow. CD117 may also be found in higher than normal amounts, or in a changed form, on some types of cancer cells, including gastrointestinal stromal tumors and melanoma.

What is positive for kit?

Are c-Kit mutations inherited?

In most cases, these KIT gene mutations are acquired during a person’s lifetime and are called somatic mutations. Somatic mutations, which lead to sporadic GISTs, are present only in the tumor cells and are not inherited.

What does CD117 mean?

CD117 is a type of receptor tyrosine kinase and a type of tumor marker. Also called c-kit and stem cell factor receptor.

What does positive for CD117 mean?

Other mesenchymal tumors that were variably CD 117 positive included clear cell sarcoma (7 of 15), metastatic melanoma (9 of 25), and malignant fibrous histiocytoma (1 of 20). These results indicate that CD117 is a specific marker for GIST among tumors that occur in the GI tract and adjacent regions.

What does CD117 negative mean?

CONCLUSION: CD117-negative KIT mutated GISTs account for approximately 6% of the gastrointestinal mesenchymal tumors. Tumor recurrence or distant metastasis correlates to both the KIT mutations at codons 557/558 and the mitotic counts, but not to the tumor size.

How can I use antibodies that detect c-kit (CD117) in clinical applications?

Antibodies that detect c-Kit (CD117) can be used in several scientific applications, including Western Blot, Flow Cytometry, Immunohistochemistry (Paraffin), ELISA View more

How are the antibodies purified from c-kit?

The antibodies are purified by protein A and peptide affinity chromatography. c-Kit is a member of the subfamily of receptor tyrosine kinases that includes PDGF, CSF-1, and FLT3/flk-2 receptors (1,2).

What is the difference between c-KIT and polyclonal antibodies?

c-Kit Antibody detects endogenous levels of c-Kit. It does not cross-react with other receptor tyrosine kinase family members. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the residues surrounding Met720 of human c-Kit.

What is CPASS™ SARS-Cov-2 neutralization antibody detection kit?

The cPass™ SARS-CoV-2 Neutralization Antibody Detection Kit is a Blocking Enzyme- Linked Immunosorbent Assay (ELISA) intended for qualitative direct detection of total neutralizing antibodies to SARS-CoV-2 in human serum and K 2-EDTA plasma. The cPass™ SARS-CoV-