What does RET gene produce?

What does RET gene produce?

The RET gene provides instructions for producing a protein that is involved in signaling within cells.

What type of gene is RET?

RET (Ret Proto-Oncogene) is a Protein Coding gene. Diseases associated with RET include Hirschsprung Disease 1 and Thyroid Carcinoma, Familial Medullary. Among its related pathways are Development of ureteric collection system and RET signaling.

How is RET gene inherited?

Everyone has two copies of the RET gene, which we randomly inherit from each of our parents. Mutations in one copy of the RET gene can increase the chance for you to develop certain types of cancer in your lifetime.

What does RET gene stand for?

Structure. RET is an abbreviation for “rearranged during transfection”, as the DNA sequence of this gene was originally found to be rearranged within a 3T3 fibroblast cell line following its transfection with DNA taken from human lymphoma cells. The human gene RET is localized to chromosome 10 (10q11.

Is the RET gene a proto-oncogene?

The ret proto-oncogene (RET) encodes the tyrosine kinase receptor of growth factors belonging to the glial-derived neurotrophic factor family. RET rearrangement has been described as a distinct molecular subset of NSCLC.

Is RET proto-oncogene?

The RET proto-oncogene, located on chromosome subband 10q11. 2, encodes a receptor tyrosine kinase expressed in tissues and tumors derived from neural crest.

What is RET point mutation?

RET point mutations, which are just a single mutation in a gene sequence, are usually associated with medullary thyroid cancer. And in medullary thyroid cancer there can be those mutations in 2 different formats, 1 of which is a sporadic mutation and the other 1 is a hereditary mutation.

Is RET a tumor suppressor gene?

In summary, we have identified RET as a novel tumor suppressor gene in the colon and have provided evidence that it can induce apoptosis and suppress anchorage independent growth in colon cancer cells when expressed in the absence of GDNF.

Is RET a growth factor receptor?

Introduction. RET (REarranged during Transfection) is a transmembrane receptor tyrosine kinase that can function as a growth factor receptor or as an oncogenic protein.

What test is RET?

In summary, RET proto-oncogene tests can be used to identify familial disease-causing RET point mutations in members of families known to be affected by inherited MTC.

What is the function of RET?

RET is a receptor tyrosine kinase (RTK) that plays key roles during embryonic development of central and peripheral (enteric) nervous systems, kidney and Peyer’s patch organogenesis and spermatogenesis (Mulligan 2014).

Is RET an oncogene or tumor suppressor?

RET is a potential tumor suppressor gene in colorectal cancer.

Is RET proto oncogene?

Is RET a tyrosine kinase?

Abstract. Rearranged during transfection (RET) is the tyrosine kinase receptor that under normal circumstances interacts with ligand at the cell surface and mediates various essential roles in a variety of cellular processes such as proliferation, differentiation, survival, migration, and metabolism.

What is RET Signalling?

RET is a member of the receptor tyrosine kinase (RTK) superfamily, which can transduce signalling by glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) in cultured cells.

What is RET positive?

A positive test for the RET biomarker means that you are eligible for targeted therapy. Targeted therapy drugs keep cancer from growing and spreading. These drugs may have fewer side effects than chemotherapy. The U.S. Food and Drug Administration has approved. two drugs to treat RET+ cancers.

What does high RET he mean?

RET-He is used for monitoring erythropoietin (EPO) and/or IV iron therapy. If the value increases it indicates the therapy is having a positive effect.

What is RET gene fusion?

Molecular biology of RET gene fusions RET fusions are caused by chromosomal rearrangements consisting of the juxtaposition of the C-terminal region of the RET protein with the N-terminal portion of another protein, leading to constitutive activation of the RET kinase [9].